Nis symporter

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Webb1 apr. 2001 · Eleven of the 12 benign nodules demonstrated less sodium iodine symporter (NIS) expression (log scale, y axis) than the surrounding normal tissue (49% decrease; range, 2–96%; P = .04). Webb21 feb. 2024 · The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. NIS also transports other monovalent anions such as tetrafluoroborate (BF4-), pertechnetate (TcO4-), and thiocyanate (SCN-), and is competitively inhibited by perchlorate (ClO4-). However, the mechanisms of substrate …

SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in …

WebbActive iodide transport into thyroid fol-licular cells is mediated by the sodium/iodide symporter (NIS), powered by Na+/K+-ATPase. NIS is expressed also in extra thyroidal tissues, most abundantly in gastric mucosa - the focus of this thesis. Cellular localisation of … Webb17 dec. 2024 · Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS).Due to its iodide trapping activity, NIS is a powerful theranostic tool for diagnostic imaging and the application of therapeutic radionuclides. birthday cards for fitness freaks

Inter-species variation in monovalent anion substrate ... - PLOS

Webb11 jan. 2024 · This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus carrying the human NIS and IFN beta genes (VSV-hIFNbeta-sodium iodide symporter [NIS]) with or without ruxolitinib phosphate in treating patients with multiple myeloma, acute myeloid leukemia, lymphomas, or … Webb19 apr. 2024 · This phase I trial studies the side effects and best dose of vesicular stomatitis virus-human interferon beta-sodium iodide symporter (VSV-hIFNbeta-NIS) with or without ruxolitinib phosphate in treating patients with stage IV endometrial cancer or endometrial cancer that has come back. WebbResponses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5) protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated 131I … danish norwegian mutually intelligible

Symport definition of symport by Medical dictionary

The sodium/iodide symporter: State of the art of its molecular ...

WebbThe sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role WebbThe Na+/I- symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones. As a result of the isolation of the … danish nosh caulfieldWebb3 maj 2024 · Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy … danish ntp server

"WebbNIS (Na+ / I- symporter) 1. De La Vieja, A. and P. Santisteban, Role of iodide metabolism in physiology and cancer. Endocrine-Related Cancer,... 2. Portulano, C., M. Paroder … " - Nis symporter

Nis symporter

Extracellular vesicles deliver sodium iodide symporter protein and ...

WebbLane 1: Mouse Stomach tissue lysates; Lane 2: Rat Stomach tissue lysates probed with NIS Polyclonal Antibody, Unconjugated (bs-0448R) at 1:200 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C. 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. WebbThe Na (+)/I (-) symporter (NIS) is an integral plasma membrane glycoprotein that mediates active I (-) transport into the thyroid follicular cells, the first step in thyroid …

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Webb16 jan. 2024 · The sodium iodide symporter (NIS), a transmembrane glycoprotein on the basolateral membrane of thyroid cells that actively participates in sodium and ion co … WebbSodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas. our results established NIS as a carrier protein that interacts with a major cell signaling hub to facilitate tumor cell locomotion and invasion.

Webbsymport: [ sim´port ] a transport mechanism that moves two compounds simultaneously across a cell membrane in the same direction, one compound being transported down a concentration gradient and the other against a gradient . See also antiport and cotransport . WebbThe sodium-iodide symporter (NIS) is a member of the sodium/solute symporter family that actively transports iodide across the membrane of the thyroid follicular cells. In …

WebbAdequate concentration of iodide ions within thyroid epithelial cells, which is mediated by the sodium iodide symporter (NIS), is essential for proper thyroid hormone synthesis. … WebbRecombinant adenovirus can guide NIS and TPO gene's expression.%目的:构建在人瑞粒酶逆转录酶 (hTERT)核心启动子引导钠碘转运体 (NIS)基因的重组腺病毒.方法:PCR扩增目的片断；通过荧光分析实验,选取启动效果最好的hTERT启动子片断；建立3个重组腺病毒:Ad-hTERT-N1S、Ad-CMV-NIS及AdCMV ...

WebbNIS - What does NIS stand for? The Free Dictionary NIS Also found in: Dictionary, Thesaurus, Medical, Financial, Encyclopedia, Wikipedia . Category filter: Copyright 1988-2024 AcronymFinder.com, All rights reserved. Suggest new definition Want to thank TFD for its existence?

WebbBackground: We aimed to determine the feasibility of monitoring viral delivery and initial distribution to solid tumors using iodinated contrast agent and micro-computed tomography (CT). Methods: Human BxPC-3 pancreatic tumor xenografts were established in nude mice. An oncolytic measles virus with an additional transcriptional unit encoding the … danish nosh bakeryWebb8 apr. 2024 · The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I-) transport into the thyroid gland, the first step in … danish nursing registrationWebb22 CH. SPITZWEG, J.C. MORRISHORMONES 2002, 1(1):22-34 Sodium Iodide Symporter (NIS) and Thyroid Christine Spitzweg 1, John C. Morris 2 Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Germany 1, and Division of Endocrinology, Mayo Clinic & Medical School, 200 First … danish number codeWebbSynonyms: I-1, IR1, IRAS, hIRAS Species: Human NISCH (11188), Mouse Nisch (64652), Rat Nisch (306255), Zebrafish... Summary: This gene encodes a … birthday cards for free downloadWebb13 apr. 2024 · HIGHLIGHTS who: The sodium iodide symporter et al. from the Nelson at the Ludwig-Maximilians-University in Munich and are summarized in this reviewSynthetic polyplexes and mesenchymal stem cells can deliver anti-cancer … The sodium iodide symporter ( nis ) as theranostic gene: its emerging role in new imaging modalities and … birthday cards for femaleWebb3 dec. 2013 · 在甲状腺先天性疾病中,经过多年的研究,人们认识到 NIS 基因突变导致先天性N1S 蛋白功能异常是一个重要的原因.基因突变可发生在多个位置, … birthday cards for four year oldsWebbNIS sodium iodine symporter PET positron emission tomography Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-008-0883-1 M. Luster (*): M. Lassmann Department of Nuclear Medicine, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany e-mail: [email protected] M. Lassmann e-mail: … danish numbering system